Crystallization methods developed for soluble proteins are often inefficient for membrane proteins with very low solubility. Detergent is often used to increase the amount of dissolved membrane proteins, and in some cases the solubility problem can be resolved by the application of the vapor diffusion method. Lipidic Cubic Phase (LCP) crystallization is one of the most popular methods to determine the structure of membrane proteins. To further increase success rate, Creative Biostructure utilizes a novel solution called Controlled In Meso Phase (CIMP) crystallization, which combines the features of well-established vapor diffusion method and LCP crystallization. CIMP Crystallization service https://www.creative-biostructure.com/controlled-in-meso-phase-cimp-crystallization-474.htm

Poly(A) RNA sequencing (RNA-seq) is a next-generation sequencing-based method to comprehensively analyze RNAs with poly(A) tails such as message RNAs (mRNAs) and long non-coding RNAs (lncRNAs). This technique accurately reveals the level of gene expression in your biological sample under specific conditions and generates a complete picture of the transcriptome for the identification of novel alternative splicing, transcripts, gene fusion events, etc. poly a rna https://rna.cd-genomics.com/polya-rna-seq.html

UMI small RNA sequencing (RNA-seq) is a unique molecular identifier (UMI)-based technology for accurate qualitative and quantitative analysis of multiple small RNAs in cells. PCR amplification bias can be removed by adding UMI into each cDNA segment, achieving accurate and unbiased quantification. UMI small RNA-seq can accurately identify SNP, quantify low-abundance transcripts, and reveal comprehensive transcriptome information. We provide UMI small RNA-seq to help you analyze microRNA (miRNA), small interfering RNA (siRNA), piwi-interacting RNA (piRNA) at one time. umi rna seq https://rna.cd-genomics.com/umi-small-rna-seq.html

We provide professional food microbiological testing uing genomics methods including 16S/18S/ITS sequencing, metagenomics, and whole genome sequencing. food microbiology https://www.cd-genomics.com/microbioseq/food-microbiological-testing.html

We provide comprehensive microbiological testing of sewage sludges based on our high-throughput sequencing technology platforms and expertise in bioinformatics analysis.We provide comprehensive microbiological testing of sewage sludges based on our high-throughput sequencing technology platforms and expertise in bioinformatics analysis. "activated sludge microbiology " https://www.cd-genomics.com/microbioseq/microbial-analysis-of-sewage-sludges.html

Long reads are excellent tools for assembling complete genomes, organizing highly repetitive regions of the genome, determining the location of removable genetic elements, and methylation studies. At CD Genomics, we are providing long-read sequencing services, including PacBio Sequel and Oxford Nanopore library preparation and sequencing services. long-read-sequencing https://longseq.cd-genomics.com/services.html

As a leading genomics company, CD Genomics provides next-generation sequencing and bioinformatics services to pharmaceutical and biotech companies, as well as academic and government agencies around the world, relying on advanced sequencing instruments and rich project experience. pacbio-hifi-sequencing https://longseq.cd-genomics.com/pacbio-smrt-sequencing-technology.html

As one of the leading providers of 16S/18S/ITS amplicon sequencing data analysis, CD Genomics uses bioinformatics to help you detect the diversified environmental microorganisms in one step. Our unique data analysis platform can also meet customers' personalized data analysis needs and provide you with a fast analysis cycle and a high-quality result report. its analysis https://bioinfo.cd-genomics.com/16s-18s-its-amplicon-sequencing.html

As a provider of 10x genomics single cell RNA-Seq data analysis, CD Genomics uses bioinformatics to help you explore the secrets of individuals biologically through cells. Our unique data analysis techniques will meet our customers' personalized data analysis needs. We provide a high-quality data analysis platform, a time-efficient analysis, and a high-quality study report. 10x genomics scrna seq https://bioinfo.cd-genomics.com/10x-genomics-single-cell-rna-seq-analysis.html

CD Genomics is offering high-throughput and cost-efficient lncRNA sequencing service by combining the latest Illumina sequencing instruments and advanced bioinformatics analysis. lncrna sequence https://www.cd-genomics.com/lncRNA.html

CD Genomics has been providing the flexible and affordable whole exome sequencing service for couple of years. We employ Illumina HiSeq sequencing platform to obtain the genetic variations information in a more efficient way. exome sequencing https://www.cd-genomics.com/Whole-Exome-Sequencing.html

Direct reprogramming has now been applied in farm animals and has transformed the establishment of pluripotent stem cells (PSCs) in many animal species around the world. The iPSCs generated from different types of somatic cells through multiple cell reprogramming strategies represent an ethically acceptable, virtually unlimited and individual-specific source of pluripotent cells. Generation of iPSCs from domesticated animals https://www.reprogramming-tech.com/farm-animals-ipsc-reprogramming-service.html

The skin is the largest organ of the body and has multiple important functions such as maintaining the stability of the body's internal environment, protecting the body's tissues and organs from external aggressions, and sensing stress, pain and temperature. Reprogramming-Skin-Cells-into-iPSCs https://www.reprogramming-tech.com/skin-cell-reprogramming-service.html

Creative Bioarray offers a wide range of biofluids obtained from both healthy patients and those with medical conditions, as well as those obtained using thousands of different analytes with corresponding test results. Our biofluid samples cover all age groups. The biofluid subtypes are program dependent and consist of combinations of cerebrospinal, lymph, amniotic, synovial and ascites fluids, as well as urine and saliva. Human Biofluids https://www.histobiolab.com/biofluids.html

Creative Bioarray provides a complete range of digital pathology services to promote work processes and improve work efficiency，relying on advanced AI technology and medical image analysis technology. Digital Pathology Solution https://www.histobiolab.com/digital-pathology-services.html

Halogenated nucleotides such as the pyrimidine analog bromodeoxyuridine (BrdU) can be used to label nascent DNA in viable cells. During the process of DNA replication, BrdU can replace thymidine and incorporate into the synthesized DNA of actively dividing cells. methods for labelling nascent DNA http://cellassay.creative-bioarray.com/services/brdu-cell-proliferation-assay.htm

Cell necrosis is a permanent cell or living tissue death induced by external or internal physical (heat, stress, radiation), chemical (strong alkali, strong acid and poison), or biological (endotoxin and pathogen) factors. Necrosis is chaotic, disorderly, and uncontrollable. Once it happens, it is difficult to reverse. cell necrosis mechanism analysis http://cellassay.creative-bioarray.com/cell-necrosis-assay.htm

Creative Bioarray provides customized solutions based on different cell invasion assays according to different requirements to accelerate your fundamental research and drug development projects. Cell-Invasion-Assays https://cell.creative-bioarray.com/cell-invasion-assays.html

Creative Bioarray provides cytotoxicity assays to determine the number of viable and dead cells in a cell population after treatment with compounds, pharmaceutical substances or other stimuli to assess the effect on cell viability. We offer cell-based high-content cytotoxicity screening services to help in drug screening and toxicity evaluation. Our professional services can help you accelerate the process of drug discovery and development. Cytotoxicity Assays https://cell.creative-bioarray.com/cytotoxicity-assays.html

Parkinson's disease (PD) is currently the second most common age-related neurodegenerative disease after Alzheimer's disease, mainly affecting the motor system, resulting in progressive death of dopamine-generating cells in the substantia nigra pars compacta (SNpc). Beside the most obvious symptoms, movement-related symptoms such as shaking, rigidity, slowness of movement and gait, patients develop non-motor symptoms, afflicting personality and behavior (depression, anxiety, apathy), as well disturbances in cognitive function. Parkinson's Disease Model https://acroscell.creative-bioarray.com/parkinson-s-disease-model.html

Xenopus laevis (the African clawed frog) oocytes are a popular model system for a wide variety of biological studies. Microinjection of DNA or messenger RNA (mRNA) into the Xenopus oocytes leads to the functional expression of the encoded proteins. The proteins expressed in such a new environment can be functionally characterized under well-defined conditions. This makes oocytes an important expression system for studies of molecular biology and electrophysiology. Such an in vitro expression system is particularly suitable for studying not only the structure and functions of cloned and mutated proteins but also the physiology of neurotransmitter receptors, ion channels, and transporters. Xenopus Oocyte Screening Model https://acroscell.creative-bioarray.com/xenopus-oocyte-screening-model.html

The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation and administration. MALDI-TOF-MS provides accurate mass measurement and high-throughput analysis of intact biomolecules ranging from 1 to 100 kDa. This technique can reveal detailed structural information at the molecular level through ion fragments of small molecule samples in 5 minutes. Compared to ESI-MS technology, MALDI-TOF produces fewer multi-charged ions and allows full-spectrum analysis of protein samples without additional deconvolution steps. maldi tof https://www.creative-proteomics.com/pronalyse/maldi-tof-for-intact-mass.html

Circular dichroism (CD) spectroscopy is a fast, simple, and accurate method for studying protein structures in dilute solutions. The structural analysis was performed using the circular dichroism of proteins and the difference in absorption of left and right circularly polarized light by asymmetric molecules. near uv circular dichroism https://www.creative-proteomics.com/pronalyse/circular-dichroism-spectroscopy-near-uv.html

Creative Proteomics provides high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) based methods for rutin analysis, which provides sufficient stability, sensitivity and high resolution for identification and quantification of rutin. This approach has the advantages of simple, stable, fast, accurate, specific and reproducible, which can help researchers to analyze rutin effectively. Rutin Analysis https://metabolomics.creative-proteomics.com/rutin-analysis-service.htm

delphinidin https://metabolomics.creative-proteomics.com/delphinidin-analysis-service.htm

Although LPA had been viewed just as a metabolic intermediate in de novo lipid synthetic pathways, it has recently been paid much attention as a lipid mediator that induces many kinds of cellular processes including cell proliferation, prevention of apoptosis, cell migration, cytokine and chemokine secretion, platelet aggregation, smooth muscle contraction, transformation of smooth muscle cells and neurite retraction. lysophosphatidic acid assay https://lipidomics.creative-proteomics.com/lysophosphatidic-acid.htm

Creative Proteomics uses Progenesis QI (Waters) and LipidSearch (Thermo) and MS DIAL for our Lipidomics Statistics. lipidomics data analysis https://lipidomics.creative-proteomics.com/lipidomics-statistics.htm

Biolayer interferometry (BLI) is a label-free optical technology used to measure intermolecular interactions. It has the advantages of high sensitivity, high throughput, and low vibration/mechanical noise. This technology uses a biosensor with a coated tip (biological layer), immobilizes the bait molecule on the sensor, and then exposes the biosensor tip to buffer conditions and light to monitor the target molecule in real time by recording changes in light interference. biolayer interferometry protein-protein https://www.iaanalysis.com/biolayer-interferometry-bli-platform.html

Drug Affinity Responsive Target Stability (DARTS) technology is an effective method for detecting novel small molecule protein targets.DARTS can be used to validate known small molecule-protein interactions and to find potential protein targets for natural products. darts assay https://www.iaanalysis.com/drug-affinity-responsive-target-stability-darts-analysis-service.html

Creative Proteomics can provide you with multi-factor detection services in cytokine storm. Simultaneously quantify multiple soluble immune biomarkers from a single sample. cytokine bead array flow cytometry https://cytokine.creative-proteomics.com/flow-cytometry-cytokine-assay.htm

Creative Proteomics provides IGF detection services and selects proprietary solutions based on your samples and requirements to assist your experiment. insulin like growth factor https://cytokine.creative-proteomics.com/igf-detection-service.htm

Phenolic acids, also known as phenolcarboxylic acids, are types of aromatic acid compound. They are also a subclass of a larger category of metabolites commonly referred to as “phenolics”. The term phenolics consists of approximately 8000 naturally occurring compounds, all of which have one common structural feature, a phenol (an aromatic ring bearing at least one hydroxyl substituent). Phenolic Acids https://www.creative-proteomics.com/services/phenolic-acids-analysis-service.htm

Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitation. iTRAQ Labeling https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm

Creative Biogene has rich experience in mitochondrial research, and the established mitochondrial staining preparation scheme has high sensitivity and wide applicability, which can meet your needs for follow-up research on mitochondrial physiological function and labeling experiments. Mitochondrial Staining https://www.mitochondriasci.com/mitochondrial-staining.html

Parallel reaction monitoring (PRM) technology uses high resolution and high precision mass spectrometry to target and quantify sample protein according to known or hypothetical information from the mass spectrometry detection law. It can selectively detect and accurately quantify the target protein/peptide. PRM Study https://www.mitochondriasci.com/prm.html

UniFrac analysis uses the evolutionary information between each sample sequence to compare whether environmental samples have significant differences in microbial communities in a specific evolutionary lineage. UniFrac can be applied to the evaluation and analysis of beta diversity, that is, the UniFrac distance matrix between samples can be obtained by comparing the two samples. UniFrac Analysis https://www.microbialtec.com/unifrac-analysis.html

The rarefaction technique was developed by Howard Sanders in the biodiversity analysis of Marine benthic ecosystems in 1968. The rarefaction curve is to randomly select a certain number of individuals from the sample, and count the number of species represented by these individuals. The curve is composed of the number of individuals and species. It can be used to compare the abundance of species in samples with different sequencing data volumes, and explain whether the amount of sequencing data of a sample is reasonable. Rarefaction Curve https://www.microbialtec.com/rarefaction-curve.html

More than 200 currently used drugs are associated with ophthalmic toxicity due to adverse drug reactions. The toxic effects of drugs on vision are significant, with approximately 6.8% of drugs removed from clinical trials because of visual toxicity. Zebrafish Ocular Toxicity Assessments https://zebrafish.creative-biogene.com/zebrafish-ocular-toxicity.html

Due to small size, high fecundity, optical transparency and similarity to humans in genetics and anatomy, zebrafish (Danio rerio) has served as a novel mainstream vertebrate model with significant advantages in studying developmental genetics and human diseases. Zebrafish Reporter Lines Generation https://zebrafish.creative-biogene.com/zebrafish-reporter-lines-generation.html

Respiratory Enteric Orphan virus (reovirus) is widely prevalent in the human population but not associated with any known human disease. Reovirus has been isolated from the respiratory and gastrointestinal tracts and is described as an "orphan" virus because the infection is asymptomatic. Recombinant reoviruses amplification https://qvirus.creative-biogene.com/services/oncolytic-reovirus-service.html