Cell necrosis is a permanent cell or living tissue death induced by external or internal physical (heat, stress, radiation), chemical (strong alkali, strong acid and poison), or biological (endotoxin and pathogen) factors. Necrosis is chaotic, disorderly, and uncontrollable. Once it happens, it is difficult to reverse. cell necrosis mechanism analysis http://cellassay.creative-bioarray.com/cell-necrosis-assay.htm

Creative Bioarray provides customized solutions based on different cell invasion assays according to different requirements to accelerate your fundamental research and drug development projects. Cell-Invasion-Assays https://cell.creative-bioarray.com/cell-invasion-assays.html

Creative Bioarray provides cytotoxicity assays to determine the number of viable and dead cells in a cell population after treatment with compounds, pharmaceutical substances or other stimuli to assess the effect on cell viability. We offer cell-based high-content cytotoxicity screening services to help in drug screening and toxicity evaluation. Our professional services can help you accelerate the process of drug discovery and development. Cytotoxicity Assays https://cell.creative-bioarray.com/cytotoxicity-assays.html

Parkinson's disease (PD) is currently the second most common age-related neurodegenerative disease after Alzheimer's disease, mainly affecting the motor system, resulting in progressive death of dopamine-generating cells in the substantia nigra pars compacta (SNpc). Beside the most obvious symptoms, movement-related symptoms such as shaking, rigidity, slowness of movement and gait, patients develop non-motor symptoms, afflicting personality and behavior (depression, anxiety, apathy), as well disturbances in cognitive function. Parkinson's Disease Model https://acroscell.creative-bioarray.com/parkinson-s-disease-model.html

Xenopus laevis (the African clawed frog) oocytes are a popular model system for a wide variety of biological studies. Microinjection of DNA or messenger RNA (mRNA) into the Xenopus oocytes leads to the functional expression of the encoded proteins. The proteins expressed in such a new environment can be functionally characterized under well-defined conditions. This makes oocytes an important expression system for studies of molecular biology and electrophysiology. Such an in vitro expression system is particularly suitable for studying not only the structure and functions of cloned and mutated proteins but also the physiology of neurotransmitter receptors, ion channels, and transporters. Xenopus Oocyte Screening Model https://acroscell.creative-bioarray.com/xenopus-oocyte-screening-model.html

The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation and administration. MALDI-TOF-MS provides accurate mass measurement and high-throughput analysis of intact biomolecules ranging from 1 to 100 kDa. This technique can reveal detailed structural information at the molecular level through ion fragments of small molecule samples in 5 minutes. Compared to ESI-MS technology, MALDI-TOF produces fewer multi-charged ions and allows full-spectrum analysis of protein samples without additional deconvolution steps. maldi tof https://www.creative-proteomics.com/pronalyse/maldi-tof-for-intact-mass.html

Circular dichroism (CD) spectroscopy is a fast, simple, and accurate method for studying protein structures in dilute solutions. The structural analysis was performed using the circular dichroism of proteins and the difference in absorption of left and right circularly polarized light by asymmetric molecules. near uv circular dichroism https://www.creative-proteomics.com/pronalyse/circular-dichroism-spectroscopy-near-uv.html

Creative Proteomics provides high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) based methods for rutin analysis, which provides sufficient stability, sensitivity and high resolution for identification and quantification of rutin. This approach has the advantages of simple, stable, fast, accurate, specific and reproducible, which can help researchers to analyze rutin effectively. Rutin Analysis https://metabolomics.creative-proteomics.com/rutin-analysis-service.htm

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Although LPA had been viewed just as a metabolic intermediate in de novo lipid synthetic pathways, it has recently been paid much attention as a lipid mediator that induces many kinds of cellular processes including cell proliferation, prevention of apoptosis, cell migration, cytokine and chemokine secretion, platelet aggregation, smooth muscle contraction, transformation of smooth muscle cells and neurite retraction. lysophosphatidic acid assay https://lipidomics.creative-proteomics.com/lysophosphatidic-acid.htm

Creative Proteomics uses Progenesis QI (Waters) and LipidSearch (Thermo) and MS DIAL for our Lipidomics Statistics. lipidomics data analysis https://lipidomics.creative-proteomics.com/lipidomics-statistics.htm

Biolayer interferometry (BLI) is a label-free optical technology used to measure intermolecular interactions. It has the advantages of high sensitivity, high throughput, and low vibration/mechanical noise. This technology uses a biosensor with a coated tip (biological layer), immobilizes the bait molecule on the sensor, and then exposes the biosensor tip to buffer conditions and light to monitor the target molecule in real time by recording changes in light interference. biolayer interferometry protein-protein https://www.iaanalysis.com/biolayer-interferometry-bli-platform.html

Drug Affinity Responsive Target Stability (DARTS) technology is an effective method for detecting novel small molecule protein targets.DARTS can be used to validate known small molecule-protein interactions and to find potential protein targets for natural products. darts assay https://www.iaanalysis.com/drug-affinity-responsive-target-stability-darts-analysis-service.html

Creative Proteomics can provide you with multi-factor detection services in cytokine storm. Simultaneously quantify multiple soluble immune biomarkers from a single sample. cytokine bead array flow cytometry https://cytokine.creative-proteomics.com/flow-cytometry-cytokine-assay.htm

Creative Proteomics provides IGF detection services and selects proprietary solutions based on your samples and requirements to assist your experiment. insulin like growth factor https://cytokine.creative-proteomics.com/igf-detection-service.htm

Phenolic acids, also known as phenolcarboxylic acids, are types of aromatic acid compound. They are also a subclass of a larger category of metabolites commonly referred to as “phenolics”. The term phenolics consists of approximately 8000 naturally occurring compounds, all of which have one common structural feature, a phenol (an aromatic ring bearing at least one hydroxyl substituent). Phenolic Acids https://www.creative-proteomics.com/services/phenolic-acids-analysis-service.htm

Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitation. iTRAQ Labeling https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm

Creative Biogene has rich experience in mitochondrial research, and the established mitochondrial staining preparation scheme has high sensitivity and wide applicability, which can meet your needs for follow-up research on mitochondrial physiological function and labeling experiments. Mitochondrial Staining https://www.mitochondriasci.com/mitochondrial-staining.html

Parallel reaction monitoring (PRM) technology uses high resolution and high precision mass spectrometry to target and quantify sample protein according to known or hypothetical information from the mass spectrometry detection law. It can selectively detect and accurately quantify the target protein/peptide. PRM Study https://www.mitochondriasci.com/prm.html

UniFrac analysis uses the evolutionary information between each sample sequence to compare whether environmental samples have significant differences in microbial communities in a specific evolutionary lineage. UniFrac can be applied to the evaluation and analysis of beta diversity, that is, the UniFrac distance matrix between samples can be obtained by comparing the two samples. UniFrac Analysis https://www.microbialtec.com/unifrac-analysis.html

The rarefaction technique was developed by Howard Sanders in the biodiversity analysis of Marine benthic ecosystems in 1968. The rarefaction curve is to randomly select a certain number of individuals from the sample, and count the number of species represented by these individuals. The curve is composed of the number of individuals and species. It can be used to compare the abundance of species in samples with different sequencing data volumes, and explain whether the amount of sequencing data of a sample is reasonable. Rarefaction Curve https://www.microbialtec.com/rarefaction-curve.html

More than 200 currently used drugs are associated with ophthalmic toxicity due to adverse drug reactions. The toxic effects of drugs on vision are significant, with approximately 6.8% of drugs removed from clinical trials because of visual toxicity. Zebrafish Ocular Toxicity Assessments https://zebrafish.creative-biogene.com/zebrafish-ocular-toxicity.html

Due to small size, high fecundity, optical transparency and similarity to humans in genetics and anatomy, zebrafish (Danio rerio) has served as a novel mainstream vertebrate model with significant advantages in studying developmental genetics and human diseases. Zebrafish Reporter Lines Generation https://zebrafish.creative-biogene.com/zebrafish-reporter-lines-generation.html

Respiratory Enteric Orphan virus (reovirus) is widely prevalent in the human population but not associated with any known human disease. Reovirus has been isolated from the respiratory and gastrointestinal tracts and is described as an "orphan" virus because the infection is asymptomatic. Recombinant reoviruses amplification https://qvirus.creative-biogene.com/services/oncolytic-reovirus-service.html

Recombinant adenovirus (Ad) vectors are highly efficient gene transfer vectors, which are widely used in vaccine development and immunotherapy. The application of Ad vectors continues to expand all over the world due to several advantages over other vectors, including ease of vector construction, efficiency of the manufacturing process, and high vector stability. Adenovirus Harvest https://qvirus.creative-biogene.com/services/adenovirus-infection-process-and-harvest-strategy.html

Since FDA approved first siRNA-based drug (patisiran) for polyneuropathy treatment, doors have been opened to utilize siRNA as a therapeutic agent for treatment of various diseases. Recently, FDA approved second siRNA drug (Givlaari) for rare disease. Moreover, there are at least 30 siRNA-based drugs in clinical trials process for several pathological conditions such as viral infections, cancer, genetic disorders, neurological disorders and autoimmune disorders. This demonstrates the significant potential of these therapeutic strategies, which promise to be effective in a wide range of currently untreatable disorders. miRNA-based drugs https://integraterna.creative-biogene.com/application/mirna-based-drugs.html

Cancer is a class of disease that involves an uncontrolled cell growth with a potential to vigorously invade into the adjacent issue or metastasize to the distant sites of the body. With regard to the severe health problems triggered by cancer, numerous investigations applying RNA therapeutics for cancer treatment have been carried out. siRNA-based cancer therapeutics https://integraterna.creative-biogene.com/application/cancer-therapeutics.html

Creative Biogene's test kit mainly uses RT-PCR to detect the West Nile fever virus, which is essential for the rapid establishment of early diagnosis of West Nile virus infection. Our products are simple and convenient to operate, can quickly obtain accurate detection results, and have high sensitivity and specificity. It is the best choice for your related research. West Nile Fever screening https://corelab.creative-biogene.com/west-nile-fever.htm

Asthma, also known as bronchial asthma, is a chronic airway disease involving a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cellular components. Asthma is associated with airway hyperresponsiveness. Extensive and variable reversible airflow limitation usually occurs, leading to recurrent symptoms of wheezing, shortness of breath, chest tightness, and coughing. arginase antibody https://corelab.creative-biogene.com/asthma.htm

As a leading provider of gene editing service, Baseceuticals is proud to offer comprehensive CRISPR/Cas9 services. We have developed an excellent platform for gene editing with high quality and high efficiency. Depending on the excellent platform and extensive experience, our staffs have succeeded in numerous CRISPR/Cas9 projects, including gene knockout, site-directed mutation, gene knock-in and precise base editing. At Baseceuticals, one-stop CRISPR/Cas9 services are available from sgRNA design/construction to cell line generation/verification and animal model generation. Combing with preclinical animal model production, functional analysis of diseases and target therapies, our scientists will work with you closely to assist you in accelerating the project progress. CRISPR/Cas9 service https://baseceuticals.creative-biogene.com/gene-therapy/crispr-cas9-service.html

As a leading provider of gene silencing service, Baseceuticals is proud to offer high quality RNAi service for customers worldwide. Our talented researchers have established a mature and comprehensive platform to develop the advanced technologies to offer the reliable results at the most competitive price. We have assembled a professional research team with years of experience and wealthy knowledge in RNAi. We will put forward the best strategy for your projects after communication of the specific situation. At Baseceuticals, we are working with you closely to rapidly move forward the projects. RNAi technology https://baseceuticals.creative-biogene.com/gene-therapy/rnai-service.html

We specialize in a range of formulation and drug delivery technologies, from conventional liposomes, PEGylated liposomes for drug delivery to polymer microspheres and nanoparticles for enhanced drug delivery. We have strong and broad expertise and over years of experience in the drug delivery field. Our mission is to become the partner of choice as a leader in drug delivery, particularly in formulating challenging compounds with liposomes, polymers and other novel nano-enabled delivery technologies. ExplantMag Reagent https://www.cd-bioparticles.net/magnetofection-in-gene-expression

We specialize in a range of formulation and drug delivery technologies, from conventional liposomes, PEGylated liposomes for drug delivery to polymer microspheres and nanoparticles for enhanced drug delivery. We have strong and broad expertise and over years of experience in the drug delivery field. Our mission is to become the partner of choice as a leader in drug delivery, particularly in formulating challenging compounds with liposomes, polymers and other novel nano-enabled delivery technologies. Transfection System https://www.cd-bioparticles.net/transfection

Carboxyl magnetic particles are magnetic beads coated with a high density of carboxyl functional groups on the surface. Carboxyl magnetic particles are designed for the covalent binding of proteins, antibodies or other molecules by carbodiimide chemistry. Fluorescent particles are also available. They can be used as fluorescent tracers for cell surface markers in fluorescence microscopy and flow cytometry. CD Bioparticles is the leading manufacturer and supplier of Carboxyl Magnetic Particles for R&D and commercialization in a wide variety of application areas. carboxyl nanoparticles https://www.cd-bioparticles.com/product/carboxyl-list-119.html

CD Bioparticles specializes in micro-, and nanoparticles research and development. We constantly introduce new products and improve the existing portfolio. We are dedicated to providing the most comprehensive list of products and fit-for-purpose custom design services to academia as well as industrial researchers and assay developers all around the world. Our goal is to provide a trusted source for all your assay development and manufacturing needs. magnetic beads biotin https://www.cd-bioparticles.com/product/biotin-list-138.html

Creative Diagnostics provides tailored solutions to a variety of industries such as biopharma, clinical laboratories and academic research centers. Our capabilities include biologic drug monitoring and custom assay development. Human Insulin ELISA Kit https://reagents.creative-diagnostics.com/human-insulin-elisa-kit-item-deiasl302-54.html

Creative Diagnostics provides tailored solutions to a variety of industries such as biopharma, clinical laboratories and academic research centers. Our capabilities include biologic drug monitoring and custom assay development. Insulin Ab ELISA Kit https://reagents.creative-diagnostics.com/insulin-ab-elisa-kit-item-deia3820-116.html

Creative Diagnostics is a leading supplier of antibodies, viral antigens, recombinant proteins and critical assay reagents. Creative Diagnostics has been providing innovative life science solutions and building trusted partnerships for over 10 years. The company's focus is to offer products and services that help to advance the development of diagnostic assays. Cardiolipin Antibodies and Antigens https://www.creative-diagnostics.com/ivd-materials/products-Cardiolipin-345.htm

Creative Diagnostics is a leading supplier of antibodies, viral antigens, recombinant proteins and critical assay reagents. Creative Diagnostics has been providing innovative life science solutions and building trusted partnerships for over 10 years. The company's focus is to offer products and services that help to advance the development of diagnostic assays. Cathepsin G Antibodies and Antigens https://www.creative-diagnostics.com/ivd-materials/products-Cathepsin-G-344.htm

Creative Diagnostics is a leading provider of testing kits for the global food industry. With our test kits, you can implement a comprehensive food safety and quality strategy and comply with local, national and international regulations. Our experts have deep expertise in commodities and product development. Our testing kits can be applied from the raw materials to the final products throughout the entire production chain. With high sensitivity, all of our kits are easy and ready to use. cereal e coli https://www.creative-diagnostics.com/food-analysis/tag-cereals-20.htm