The development and quality assessment of biopharmaceuticals, especially protein and peptide drugs, require a series of analytical techniques to assess the integrity of bioactive molecules during formulation and administration. MALDI-TOF-MS provides accurate mass measurement and high-throughput analysis of intact biomolecules ranging from 1 to 100 kDa. This technique can reveal detailed structural information at the molecular level through ion fragments of small molecule samples in 5 minutes. Compared to ESI-MS technology, MALDI-TOF produces fewer multi-charged ions and allows full-spectrum analysis of protein samples without additional deconvolution steps. maldi tof https://www.creative-proteomics.com/pronalyse/maldi-tof-for-intact-mass.html

Circular dichroism (CD) spectroscopy is a fast, simple, and accurate method for studying protein structures in dilute solutions. The structural analysis was performed using the circular dichroism of proteins and the difference in absorption of left and right circularly polarized light by asymmetric molecules. near uv circular dichroism https://www.creative-proteomics.com/pronalyse/circular-dichroism-spectroscopy-near-uv.html

Creative Proteomics provides high performance liquid chromatography-mass spectrometry (HPLC-MS/MS) based methods for rutin analysis, which provides sufficient stability, sensitivity and high resolution for identification and quantification of rutin. This approach has the advantages of simple, stable, fast, accurate, specific and reproducible, which can help researchers to analyze rutin effectively. Rutin Analysis https://metabolomics.creative-proteomics.com/rutin-analysis-service.htm

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Although LPA had been viewed just as a metabolic intermediate in de novo lipid synthetic pathways, it has recently been paid much attention as a lipid mediator that induces many kinds of cellular processes including cell proliferation, prevention of apoptosis, cell migration, cytokine and chemokine secretion, platelet aggregation, smooth muscle contraction, transformation of smooth muscle cells and neurite retraction. lysophosphatidic acid assay https://lipidomics.creative-proteomics.com/lysophosphatidic-acid.htm

Creative Proteomics uses Progenesis QI (Waters) and LipidSearch (Thermo) and MS DIAL for our Lipidomics Statistics. lipidomics data analysis https://lipidomics.creative-proteomics.com/lipidomics-statistics.htm

Biolayer interferometry (BLI) is a label-free optical technology used to measure intermolecular interactions. It has the advantages of high sensitivity, high throughput, and low vibration/mechanical noise. This technology uses a biosensor with a coated tip (biological layer), immobilizes the bait molecule on the sensor, and then exposes the biosensor tip to buffer conditions and light to monitor the target molecule in real time by recording changes in light interference. biolayer interferometry protein-protein https://www.iaanalysis.com/biolayer-interferometry-bli-platform.html

Drug Affinity Responsive Target Stability (DARTS) technology is an effective method for detecting novel small molecule protein targets.DARTS can be used to validate known small molecule-protein interactions and to find potential protein targets for natural products. darts assay https://www.iaanalysis.com/drug-affinity-responsive-target-stability-darts-analysis-service.html

Creative Proteomics can provide you with multi-factor detection services in cytokine storm. Simultaneously quantify multiple soluble immune biomarkers from a single sample. cytokine bead array flow cytometry https://cytokine.creative-proteomics.com/flow-cytometry-cytokine-assay.htm

Creative Proteomics provides IGF detection services and selects proprietary solutions based on your samples and requirements to assist your experiment. insulin like growth factor https://cytokine.creative-proteomics.com/igf-detection-service.htm

Phenolic acids, also known as phenolcarboxylic acids, are types of aromatic acid compound. They are also a subclass of a larger category of metabolites commonly referred to as “phenolics”. The term phenolics consists of approximately 8000 naturally occurring compounds, all of which have one common structural feature, a phenol (an aromatic ring bearing at least one hydroxyl substituent). Phenolic Acids https://www.creative-proteomics.com/services/phenolic-acids-analysis-service.htm

Creative Proteomics offers iTRAQ protein quantification service suited for unbiased untargeted biomarker discovery. Relative quantification of proteins for biomarker discovery in complex mixtures by mass spectrometry can easily and quickly be achieved using iTRAQ technology. iTRAQ is ideally suited for comparing normal, diseased, and drug-treated samples, time course studies, biological replicates and provides relative quantitation. iTRAQ Labeling https://www.creative-proteomics.com/services/itraq-based-proteomics-analysis.htm