Kamagra Polo works by inhibiting an enzyme called phosphodiesterase type 5 (PDE5), which leads to increased blood flow in the penis during sexual arousal. The standard dosage typically involves taking one tablet about 30 minutes to an hour before sexual activity. While Kamagra Polo can be effective for treating ED, its impact on the cardiovascular system necessitates caution, especially for those with pre-existing heart conditions.